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ValueScreener company report

Prelude Therapeutics Incorporated (PRLD)

NASDAQ / Healthcare / Biotechnology

Share price

3.26 USD Market dataClose of Oct 16, 2026

Market capitalisation

188.7M USD Market dataClose of Oct 16, 2026
Market data
Oct 16, 2026
Filed accounts
FY2025, filed Mar 10, 2026
Ratios computed
Oct 16, 2026
Filed years
7, FY2019 to FY2025
Four kinds of sourceSEC filingCompany statementMarket dataComputedWhat each means
SEC filingFiled with the SEC
Read from a statement the company filed with the SEC, with the form, fiscal year, filing date and accession beside it.
Company statementCompany statement
What the company says about itself in a filing: an 8-K item, the auditor, its own segment names.
Market dataMarket data
Prices, market value and what analysts publish, with the date they are as of.
ComputedComputed by ValueScreener
Worked out by us from the other three, with the inputs and the formula one press away. A score is a research output, not a rating or a recommendation.
Reading

1 of 10

Overview

What the business is, what it costs, and how it reads on four questions.

Market dataSEC filingComputed

Four questions, at a glance

Quality

Return on equity

-145.0% Computed

From the FY2025 filing

Read quality

Valuation

Price to book

3.66x Computed

FY2025 accounts, priced at the latest close

Read valuation

Cash generation

Free cash flow yield

-22.5% Computed

FY2025 accounts, priced at the latest close

Read cash generation

Revenue and net income, by fiscal year

FY2018 Net income: -14.7M USDFY2019 Net income: -27.6M USDFY2020 Net income: -56.9M USDFY2021 Net income: -111.7M USDFY2022 Net income: -115.4M USDFY2023 Net income: -121.8M USDFY2024 Revenue: 7.0M USDFY2024 Net income: -127.2M USDFY2025 Revenue: 12.1M USDFY2025 Net income: -99.5M USD
Revenue Net income8 fiscal years; a year whose statement names no SEC filing is market data, and the table in Filings says which.
Named tests met
0 of 30 Which tests
The business, and the score behind its five axes

The reading, in brief

Is it good

Return on equity was -145.0% in FY2025, in the band labelled "Likely below the cost of equity" (below 8.0%), on lines anchored on Damodaran's cost-of-capital data, suggesting returns on shareholders' money below the usual cost of equity.

Today, against the Biotechnology industry (494 companies), -145.0% sits at the 25th percentile; the middle half of that group runs from -146.9% to -28.9%.

Is it safe

Debt to equity was 0.26 in FY2025, in the band labelled "Conservative" (below 0.50), on lines anchored on Graham's defensive-investor criteria, suggesting a balance sheet that relies little on borrowing.

Today, against the Biotechnology industry (252 companies), 0.26 sits at the 74th percentile; the middle half of that group runs from 0.01 to 0.29.

Year by year against peers
Whether Prelude Therapeutics Incorporated's return on equity stayed above the median of the Biotechnology industry, year by year. (FY2023 to FY2025, 3 fiscal years of Prelude Therapeutics Incorporated with a comparable figure)
The direction
Which way Prelude Therapeutics Incorporated's current ratio has moved, and how steadily. (FY2018 to FY2025, 8 filed years of Prelude Therapeutics Incorporated)
What could explain it
What in Prelude Therapeutics Incorporated's filed statements could explain the movements. (6 readings drawn from the statement lines Prelude Therapeutics Incorporated filed)
What to check next
What to check next on Prelude Therapeutics Incorporated, and where in its filings. (4 questions for Prelude Therapeutics Incorporated)
In one paragraph
One paragraph on Prelude Therapeutics Incorporated's returns, cash, balance sheet and price. (7 of sixteen figures read for Prelude Therapeutics Incorporated)

These are PRLD’s filed figures. The research desk says what they mean, against peers and its own years, with what to check next.

Research PRLDPart of Serious. New accounts start with 30 days of Professional, free, no card.

2 of 10

What changed

The newest filing, what it moved, and when the next one is due.

SEC filingCompany statement

The newest accounts on file are the FY2025 annual report: 10-K, filed Mar 10, 2026, accession 0001193125-26-099428.

3 of 10

Quality

The returns the business earns on its capital, and the margins behind them.

SEC filingComputed

Prelude Therapeutics Incorporated: returns on capital and margins, each with its source
FigureValue, source and document
Return on invested capital, after tax
Why n/a

No tax rate can be read for this year: the income tax or the pre-tax income line is not filed, or pre-tax income is zero, so after-tax operating profit is not computed.

n/a ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Return on equity-145.0% ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Return on capital employed, pre-tax-118.4% ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Return on assets-70.4% ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Gross margin
Why n/a

Our archived statements for this filer carry no gross profit line, so there is nothing to compute a gross margin from and trace back to source. That may be because the filer presents no cost of revenue, or because we have not captured the concept. We do not guess which.

n/a ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Operating margin-861.3% ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Net margin-819.6% ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
PRLD -819.6%
IPHA -546.1%ACIU -1971.7%STRO -186.4%IVA -2002.7%ALEC -679.2%
-2002.7%-186.4%
Net margin: PRLD against the 5 companies named under Valuation context, each as filed for its own latest year. Placement only: no average is drawn.

4 of 10

Financial strength

What it owes against what it owns, and whether it can meet what falls due.

SEC filingComputedCompany statement

Prelude Therapeutics Incorporated: leverage, liquidity and distress, each with its source
FigureValue, source and document
Debt to equity0.26 ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Current ratio1.99 ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Quick ratio1.99 ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Interest coverage
Why n/a

No interest expense is filed for this year, so coverage is not computed.

n/a ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Altman Z-score-6.60 ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Net debt-85.4M ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Total assets 141.3MTotal liabilities 72.7MShareholders' equity 68.6MOwnsOwes, and equity
Total assets Total liabilities Shareholders’ equity
The balance sheet, line by line

Financial health

What Prelude Therapeutics Incorporated owned and owed at the end of fiscal 2025, from the balance sheet it filed (10-K, filed Mar 10, 2026, 0001193125-26-099428).

Prelude Therapeutics Incorporated: balance sheet position
Total assets141.3M FiledFY2025 10-K, filed Mar 10, 2026
Total liabilities72.7M FiledFY2025 10-K, filed Mar 10, 2026
Shareholders' equity68.6M FiledFY2025 10-K, filed Mar 10, 2026
Cash103.2M FiledFY2025 10-K, filed Mar 10, 2026
Total debt17.8M FiledFY2025 10-K, filed Mar 10, 2026
Net debt-85.4M
Current ratio1.99
Debt to equity0.26
  • Interest cover: FY2025: No interest expense is filed for this year, so coverage is not computed.

Read from the filed balance sheet for each year, with the income statement of the same year supplying operating profit where a ratio needs it. Nothing here is a view on whether this company is sound.

5 of 10

Valuation context

What the market charges for it, against its own record and companies like it.

Market dataSEC filingComputed

Prelude Therapeutics Incorporated: what the market charges, each with its source
FigureValue, source and document
Price to earnings
Why n/m

Earnings are zero or negative, so a price to earnings multiple is not meaningful. A negative P/E is not a cheap company and a large positive one from a near-zero denominator is not an expensive one.

n/m ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
P/E on trailing twelve months
Why n/a

Fewer than twenty trading days carry a meaningful trailing price to earnings ratio, so no range is stated.

n/a ComputedClose of Oct 16, 2026 · Trailing four quarters, each as known on the day; the quarterly filings are listed under Filings
Price to book3.66x ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Price to sales20.67x ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Enterprise value to EBIT
Why n/a

We do not hold this figure for this company, so there is nothing to show.

n/a ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Enterprise value to EBITDA
Why n/m

EBITDA is zero or negative, so a multiple of it is not meaningful.

n/m ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Price to earnings over growth
Why n/m

Earnings are zero or negative, so a price to earnings multiple is not meaningful. A negative P/E is not a cheap company and a large positive one from a near-zero denominator is not an expensive one.

n/m ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Diluted earnings per share-1.29 USD FiledFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Graham number
Why n/m

Earnings are zero or negative, so a price to earnings multiple is not meaningful. A negative P/E is not a cheap company and a large positive one from a near-zero denominator is not an expensive one.

n/m ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428

We publish no fair value or price target of our own. Value PRLD on your own assumptions in the DCF workbench, starting from the filed figures.

Its own record, and companies like it

Valuation

What the market charges for Prelude Therapeutics Incorporated today, and the multiples it has carried. No value of ours: the figures are the filings’ and the market’s.

Prelude Therapeutics Incorporated: valuation
Share price3.26 USD
Market capitalisation188.7M USD
Enterprise value to EBITDAn/m
Graham numbern/m
Diluted earnings per share, FY2025-1.29 USD

Price to earnings on trailing twelve months: Fewer than twenty trading days carry a meaningful trailing price to earnings ratio, so no range is stated.

Companies like Prelude Therapeutics Incorporated

  1. Innate Pharma S.A. (IPHA)Market cap 157.5M USD
  2. AC Immune S.A. (ACIU)Market cap 243.2M USD
  3. Sutro Biopharma, Inc. (STRO)Market cap 181.4M USD
  4. Inventiva S.A. (IVA)Market cap 152.8M USD
  5. Alector, Inc. (ALEC)Market cap 205.4M USD

Same industry (Biotechnology) and size band (Micro, 50M to 300M), nearest in market value, net margin and current ratio. Each of those counts equally, by how many of the companies considered sit between the two on it. Closest first: the order is likeness and nothing else.

6 of 10

Cash generation

Whether profit arrives as cash, and what is paid back to shareholders.

SEC filingComputed

Prelude Therapeutics Incorporated: cash generation and what is paid out, each with its source
FigureValue, source and document
Free cash flow yield-22.5% ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Free cash flow-56.4M USD ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Free cash flow margin-464.3% ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Dividend yield
Why n/a

We do not hold this figure for this company, so there is nothing to show.

n/a ComputedClose of Oct 16, 2026 · FY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Payout ratio
Why n/a

We do not hold this figure for this company, so there is nothing to show.

n/a ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
FY2018 Free cash flow: -13.5M USDFY2018 Net income: -14.7M USDFY2019 Free cash flow: -26.4M USDFY2019 Net income: -27.6M USDFY2020 Free cash flow: -46.8M USDFY2020 Net income: -56.9M USDFY2021 Free cash flow: -85.9M USDFY2021 Net income: -111.7M USDFY2022 Free cash flow: -86.7M USDFY2022 Net income: -115.4M USDFY2023 Free cash flow: -110.6M USDFY2023 Net income: -121.8M USDFY2024 Free cash flow: -103.7M USDFY2024 Net income: -127.2M USDFY2025 Free cash flow: -56.4M USDFY2025 Net income: -99.5M USD
Free cash flow Net incomeProfit that arrives as cash stands level with net income; a gap year after year is worth reading about.

7 of 10

Filings

Every figure, the year it is for and the document it was read from.

SEC filingMarket data

The filed figures

Computed from the accounts this company filed with the SEC and, in a ratio with a price in it, the last close, dated on this page. Every filed figure below carries the fiscal year and the filing date its accounts were read from, and every blank carries the reason it is blank. Nothing here is a view on this company.

Prelude Therapeutics Incorporated: the eight ratios, with the fiscal year and filing date behind each.
FigureValueYearAs of
n/mFY2025Oct 16, 2026
n/m Not meaningful for this company, such as a P/E on negative earnings or a bank's EV/EBIT.
3.66xFY2025Oct 16, 2026
n/aFY2025Oct 16, 2026
n/a Operating profit is zero or negative, so there is no profit for a buyer's price to be a multiple of.
-22.5%FY2025Oct 16, 2026
n/aFY2025Mar 10, 2026
n/a No tax rate can be read for this year: the income tax or the pre-tax income line is not filed, or pre-tax income is zero, so after-tax operating profit is not computed.
n/aFY2025Oct 16, 2026
n/a The filed cash flow statement reports no dividend paid at all. That is not the same as a filed zero, and we will not read it as one.
0.26FY2025Mar 10, 2026
1.99FY2025Mar 10, 2026
20.67xFY2025Oct 16, 2026
n/mFY2025Oct 16, 2026
n/m Not meaningful for this company, such as a P/E on negative earnings or a bank's EV/EBIT.
-6.60FY2025Oct 16, 2026
-4.92FY2025Mar 10, 2026
3/9FY2025Mar 10, 2026

The figures are computed from the accounts for fiscal 2025, the newest full year on file. 7 filed fiscal years on record, FY2019 to FY2025, from SEC EDGAR. Prices as of Oct 16, 2026. Ratios recomputed Oct 16, 2026. Two facts, because a recompute is not a fresh quote.

The year and the filing date name the statement each figure’s accounts are read from, and they stand even where the figure itself could not be computed: the line beneath a blank says what that statement did not carry. A figure’s name opens its formula and the filings behind it; a statement that names no SEC filing has no filing date, and reads n/a.

Ten years of filed figures, year by year

Ten years of filed figures

8 fiscal years, FY2018 to FY2025. 7 read from the annual reports Prelude Therapeutics Incorporated filed with the SEC, each naming its filing; the rest from statements that name none, which are market data. Amounts in USD, as reported.

Prelude Therapeutics Incorporated: revenue, earnings, free cash flow and returns, by fiscal year, with the filing each year was read from
YearRevenueOperating incomeNet incomeEPS, dilutedFree cash flowOperating marginReturn on equityFiling
FY202512.1M-104.6M-99.5M-1.29-56.4M-861.3%-145.0%10-K, Mar 10, 20260001193125-26-099428
FY20247.0M-139.7M-127.2M-1.68-103.7M-1995.9%-96.7%10-K, Mar 10, 20250000950170-25-035921
FY2023n/a-132.3M-121.8M-2.02-110.6Mn/a-51.4%10-K, Feb 15, 20240000950170-24-016016
FY2022n/a-123.5M-115.4M-2.44-86.7Mn/a-59.1%10-K, Mar 15, 20230000950170-23-007989
FY2021n/a-113.7M-111.7M-2.43-85.9Mn/a-39.1%10-K, Mar 17, 20220001564590-22-010723
FY2020n/a-58.8M-56.9M-4.56-46.8Mn/a-26.8%10-K, Mar 16, 20210001564590-21-013330
FY2019n/a-28.1M-27.6M-16.52-26.4Mn/an/m10-K, Mar 16, 20210001564590-21-013330
FY2018n/a-15.0M-14.7M-9.31-13.5Mn/an/mMarket data, supplied Oct 15, 2026accession n/a
  • Revenue, compound annual growth FY2024 to FY2025: 73.4%
  • Earnings: Earnings was not positive in both 2018 and 2025, so a compound rate across the window is not defined. Both figures are in the table.
  • Earnings per share: Earnings per share was not positive in both 2018 and 2025, so a compound rate across the window is not defined. Both figures are in the table.
  • Free cash flow: Free cash flow was not positive in both 2018 and 2025, so a compound rate across the window is not defined. Both figures are in the table.

Every figure in this section is a line of a filed annual statement or a ratio of two of them. Nothing here is estimated or smoothed. Earnings per share filed before a share split are put on today's share count, and say so. Nothing here is a verdict on the company.

8 of 10

Risks and guardrails

The accounting screens, the published tests, and the lines you can set to be told.

ComputedCompany statement

Prelude Therapeutics Incorporated: accounting screens and published tests, each with its source
FigureValue, source and document
Beneish M-score-4.92 ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Piotroski F-score3/9 ComputedFY2025 10-K, filed Mar 10, 2026, 0001193125-26-099428
Named tests met0 of 30 Computed
Beta1.37 ComputedClose of Oct 16, 2026

The named tests

Of 30 tests value investors published: 0 met, 23 not met, 7 we could not complete. Counts, never a score: a single figure would have to decide that meeting one investor’s criteria and meeting another’s are worth the same.

Which tests, by name(all 30)
Meets
None of the named tests.
Does not
Defensive investor (Benjamin Graham); Deep value; Large cap, low P/E; High F-score, low P/B (Joseph Piotroski); Three forensic scores; High returns and growth; Gross margin, turnover (Robert Novy-Marx); EV/EBITDA and coverage; High yield, low payout; Dividends and buybacks; Low beta, profitable; Near the 52-week low; Z-score and coverage (Edward Altman); Two thirds of NCAV (Benjamin Graham); High returns, low debt; Owner earnings yield; High return on tangibles; Low P/S, rising earnings (James O'Shaughnessy); Book or below, low debt (Walter Schloss); Tangible book or below; Cash-flow yield and ROIC; Clean books, high ROIC; Cheapest quarter on P/B (David Dreman)
Not measured
Earnings yield and ROIC (Joel Greenblatt); Low PEG, low debt (Peter Lynch); ROIC at or above WACC; P/E times P/B (Benjamin Graham); Cash-covered dividend; Cheapest quarter on P/E (David Dreman); Low P/E, growth, yield (John Neff). A test with a figure we could not read is incomplete, never met and never failed.
Figures we could not read(15)
  • P/E Ratio: Earnings are zero or negative, so a price to earnings multiple is not meaningful. A negative P/E is not a cheap company and a large positive one from a near-zero denominator is not an expensive one.
  • EV/EBIT: We do not hold this figure for this company, so there is nothing to show.
  • Return on Invested Capital: No tax rate can be read for this year: the income tax or the pre-tax income line is not filed, or pre-tax income is zero, so after-tax operating profit is not computed.
  • PEG Ratio: Earnings are zero or negative, so a price to earnings multiple is not meaningful. A negative P/E is not a cheap company and a large positive one from a near-zero denominator is not an expensive one.
  • Eps Growth 5Y: We do not hold this figure for this company, so there is nothing to show.
  • Rev Growth 5Y: We do not hold this figure for this company, so there is nothing to show.
  • Gross Margin: Our archived statements for this filer carry no gross profit line, so there is nothing to compute a gross margin from and trace back to source. That may be because the filer presents no cost of revenue, or because we have not captured the concept. We do not guess which.
  • EV/EBITDA: EBITDA is zero or negative, so a multiple of it is not meaningful.
  • Interest Coverage: No interest expense is filed for this year, so coverage is not computed.
  • Dividend Yield: We do not hold this figure for this company, so there is nothing to show.
  • Payout Ratio: We do not hold this figure for this company, so there is nothing to show.
  • ROIC-WACC Spread: We do not hold this figure for this company, so there is nothing to show.
  • Price To Graham: Earnings are zero or negative, so a price to earnings multiple is not meaningful. A negative P/E is not a cheap company and a large positive one from a near-zero denominator is not an expensive one.
  • Dividend Coverage Ratio: We do not hold this figure for this company, so there is nothing to show.
  • Dividend Streak: We do not hold this figure for this company, so there is nothing to show.

9 of 10

Declared positions

Whether anybody here owns this company.

Positions declared by Javier Sanz Alvarez: no holding in any company shown here, as of October 3, 2026.

10 of 10

Next step

What to do with what you have read.

A thesis is your reason for owning it, in your words, with the figures that must stay true. Checking those figures every night against the newest filed accounts, and telling you once when one breaks, is what the subscription adds.

More on this company

What this cannot tell you

  • 15 figures could not be read on this company, among them P/E Ratio, EV/EBIT, Return on Invested Capital. Each blank in the table above names the rest, with its reason. 7 named tests come back incomplete because of them, which is neither met nor missed.
  • We hold 7 filed fiscal years rather than 10, so the run above is shorter than a full decade and is counted as what it is.

And the one that is true of all of it: This is what the numbers say today. It cannot tell you the day one of them stops being true. Nothing here can, because the reasons are not written down.

Running this once is arithmetic on public documents and you are welcome to it. Writing down why you own each company, in your own words and with the numbers that have to stay true for it to hold, and then having those numbers re-checked every night against the newest filed accounts, and against the latest close where a rule watches a price, is Professional, the plan a new account starts on for 30 days, one trial per person. It writes to you the day one breaks, and stays quiet when nothing does. The check runs every night at 23:30 UTC. A filing is picked up the night after it is published.

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ValueScreener · valuescreener.ai · Computed from accounts filed with the SEC by this company, read from EDGAR, and from dated closing prices. On this page a filed figure opens into its formula, its inputs and the statement, fiscal year and filing date it was read from, and a price into the day of its close. A figure that cannot show that trail says so.

A computation on accounts filed with the SEC, not a recommendation and not advice. Past filings do not indicate future results. Risk disclaimer.

Margin Notes

Once a week, what changed in the filings of US-listed companies, why it can matter to a thesis, and what deserves a closer review. Grounded in filings, not market noise.

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